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VRX-0466617
CAS No. 926906-64-1
VRX-0466617( VRX 0466617 | VRX0466617 )
Catalog No. M16639 CAS No. 926906-64-1
A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVRX-0466617
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM).
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DescriptionA potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM); inhibits the phosphorylation of Chk2 Ser(19) and Ser(33-35), but not of Chk2 Thr(68), prevents the IR-induced Chk2-dependent degradation of Hdmx and attenuates IR-induced apoptosis.
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In Vitro——
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In Vivo——
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SynonymsVRX 0466617 | VRX0466617
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research Area——
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Indication——
Chemical Information
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CAS Number926906-64-1
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Formula Weight462.366
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Molecular FormulaC19H20BrN5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESN/C(C1=C(NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)SNC1=O)=N\C(C)CO
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Chemical Name5-[4-(4-Bromoanilino)anilino]-N'-(1-hydroxypropan-2-yl)-3-oxo-1,2-thiazole-4-carboximidamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Carlessi L, et al. Mol Cancer Ther. 2007 Mar; 6(3):935-44.
2. Carlessi L, et al. Biochim Biophys Acta. 2010 Oct;1803(10):1213-23.
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