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XL-844
CAS No. 631864-00-1
XL-844( EXEL-9844 | EXEL9844 | XL844 )
Catalog No. M15387 CAS No. 631864-00-1
A potent, specific, orally available, ATP?competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameXL-844
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, orally available, ATP?competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
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DescriptionA potent, specific, orally available, ATP?competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively; increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry; significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model.Blood Cancer Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsEXEL-9844 | EXEL9844 | XL844
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number631864-00-1
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Formula Weight287.323
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Molecular FormulaC14H17N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C(C(=C1)NC(=O)NC2=NC=CN=C2)OCCCN
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Chemical Name1-[2-(3-aminopropoxy)phenyl]-3-pyrazin-2-ylurea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Riesterer O, et al. Invest New Drugs. 2011 Jun;29(3):514-22.
2. Matthews DJ, et al. Cell Cycle. 2007 Jan 1;6(1):104-10.
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