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VR-23
CAS No. 1624602-30-7
VR-23( VR23 )
Catalog No. M12402 CAS No. 1624602-30-7
A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 131 | In Stock |
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| 50MG | 237 | In Stock |
|
| 100MG | 403 | In Stock |
|
| 200MG | 591 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVR-23
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM).
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DescriptionA potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM); targets the β2 of the 20S proteasome catalytic subunit and structurally distinct from other known proteasome inhibitors and selectively kills cancer cells by apoptosis, with little effect on noncancerous cells.
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In VitroVR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to PS-341. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.
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In VivoVR23 shows effective antitumor and antiangiogenic activities in mice.
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SynonymsVR23
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorCaspase-likeproteasomes|Chymotrypsin-likeproteasomes|Trypsin-likeproteasomes
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1624602-30-7
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Formula Weight477.8782
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Molecular FormulaC19H16ClN5O6S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C32)CC1)(C4=C(C=C(C=C4)[N+]([O-])=O)[N+]([O-])=O)=O
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Chemical NameQuinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pundir S, et al. Cancer Res. 2015 Oct 1;75(19):4164-75.
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