VLX600

CAS No. 327031-55-0

VLX600 ( —— )

Catalog No. M21963 CAS No. 327031-55-0

VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 43 Get Quote
10MG 69 Get Quote
25MG 142 Get Quote
50MG 237 Get Quote
100MG 405 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    VLX600
  • Note
    Research use only, not for human use.
  • Brief Description
    VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent.
  • Description
    VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent.?It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.VLX600 as a drug that is preferentially active against quiescent cells in colon cancer 3-D microtissues.?The anticancer activity is associated with reduced mitochondrial respiration, leading to bioenergetic catastrophe and tumour cell death.?VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation.?Importantly, VLX600 displays tumour growth inhibition in vivo.?
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    oxidative phosphorylation (OXPHOS)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    327031-55-0
  • Formula Weight
    317.35
  • Molecular Formula
    C17H15N7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:8 mg/ml(25.21 mM)
  • SMILES
    C\C(=N/Nc1nnc2c(n1)[nH]c1c(C)cccc21)c1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xiaonan Zhang , M?rten Frykn?s , Emma Hernlund,et al. Induction of Mitochondrial Dysfunction as a Strategy for Targeting Tumour Cells in Metabolically Compromised Microenvironments[J].Nat Commun. 2014;5:3295.2. Karlsson H, et al. A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation. Oncotarget. 2019 Sep 3;10(51):5372-5382.3. Arun Kanakkanthara , Kiran Kurmi , Thomas L Ekstrom, et al.BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents[1].Cancer Res. 2019 Dec 1;79(23):5920-5929.
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