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Home - Products - PI3K/Akt/mTOR signaling - PDK - VER-246608

VER-246608

CAS No. 1684386-71-7

VER-246608( —— )

Catalog No. M23757 CAS No. 1684386-71-7

VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VER-246608
  • Note
    Research use only, not for human use.
  • Brief Description
    VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase.
  • Description
    VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PDK
  • Recptor
    PDK1|PDK2|PDK3|PDK4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1684386-71-7
  • Formula Weight
    552.96
  • Molecular Formula
    C28H23ClF2N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (180.84 mM; Need ultrasonic)
  • SMILES
    O=C(C1=CC=C(O)C=C1O)N(CC2=CC=C(CNC(C(F)F)=O)C=C2)C(C=C3)=CC=C3C4=NC(Cl)=NC=C4C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Moore JD, et al. VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget. 2014 Dec 30;5(24):12862-76.
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