
VER-246608
CAS No. 1684386-71-7
VER-246608( —— )
Catalog No. M23757 CAS No. 1684386-71-7
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 61 | In Stock |
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5MG | 102 | In Stock |
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10MG | 160 | In Stock |
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25MG | 312 | In Stock |
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50MG | 475 | In Stock |
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100MG | 692 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameVER-246608
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NoteResearch use only, not for human use.
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Brief DescriptionVER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase.
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DescriptionVER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPDK
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RecptorPDK1|PDK2|PDK3|PDK4
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Research Area——
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Indication——
Chemical Information
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CAS Number1684386-71-7
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Formula Weight552.96
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Molecular FormulaC28H23ClF2N4O4
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (180.84 mM; Need ultrasonic)
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SMILESO=C(C1=CC=C(O)C=C1O)N(CC2=CC=C(CNC(C(F)F)=O)C=C2)C(C=C3)=CC=C3C4=NC(Cl)=NC=C4C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Moore JD, et al. VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget. 2014 Dec 30;5(24):12862-76.
molnova catalog



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