VAF347

CAS No. 574759-62-9

VAF347( —— )

Catalog No. M26495 CAS No. 574759-62-9

VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 42 Get Quote
5MG 69 Get Quote
10MG 110 Get Quote
25MG 200 Get Quote
50MG 335 Get Quote
100MG 500 Get Quote
500MG 1098 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    VAF347
  • Note
    Research use only, not for human use.
  • Brief Description
    VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
  • Description
    VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.(In Vitro):In HL-60 cells, VAF347 augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of the partners in the signal body appear to be enhanced: Fgr interacts with c-Cbl, CD38, and pS259c-Raf, and AhR interacts with c-Cbl and Lyn. VAF347 enhances retinoic acid-induced cell cycle arrest.(In Vivo):AhR-deficient mice are resistant to VAF347's ability to block allergic lung inflammation in vivo.
  • In Vitro
    Cell Cycle Analysis Cell Line:HL-60 cells Concentration:10 nM, 100 nM, 1 μM, 10 μM, 20 μM Incubation Time:48 hours or 72 hours Result:Enhanced retinoic acid-induced cell cycle arrest in G1/0.Western Blot Analysis Cell Line:HL-60 cells Concentration:20 μM Incubation Time:48 hours Result:Augmented retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    574759-62-9
  • Formula Weight
    349.74
  • Molecular Formula
    C17H11ClF3N3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 31.25 mg/mL (89.35 mM)
  • SMILES
    FC(F)(F)c1ccc(Nc2nccc(n2)-c2cccc(Cl)c2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Warner SA, Eierman DF, Sovocool GW, Domnas AJ. Cycloartenol-derived sterol biosynthesis in the Peronosporales. Proc Natl Acad Sci U S A. 1982 Jun;79(12):3769-72.
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