
VAF347
CAS No. 574759-62-9
VAF347( —— )
Catalog No. M26495 CAS No. 574759-62-9
VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 42 | Get Quote |
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5MG | 69 | Get Quote |
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10MG | 110 | Get Quote |
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25MG | 200 | Get Quote |
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50MG | 335 | Get Quote |
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100MG | 500 | Get Quote |
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500MG | 1098 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameVAF347
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NoteResearch use only, not for human use.
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Brief DescriptionVAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
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DescriptionVAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.(In Vitro):In HL-60 cells, VAF347 augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of the partners in the signal body appear to be enhanced: Fgr interacts with c-Cbl, CD38, and pS259c-Raf, and AhR interacts with c-Cbl and Lyn. VAF347 enhances retinoic acid-induced cell cycle arrest.(In Vivo):AhR-deficient mice are resistant to VAF347's ability to block allergic lung inflammation in vivo.
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In VitroCell Cycle Analysis Cell Line:HL-60 cells Concentration:10 nM, 100 nM, 1 μM, 10 μM, 20 μM Incubation Time:48 hours or 72 hours Result:Enhanced retinoic acid-induced cell cycle arrest in G1/0.Western Blot Analysis Cell Line:HL-60 cells Concentration:20 μM Incubation Time:48 hours Result:Augmented retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox.
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAhR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number574759-62-9
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Formula Weight349.74
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Molecular FormulaC17H11ClF3N3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 31.25 mg/mL (89.35 mM)
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SMILESFC(F)(F)c1ccc(Nc2nccc(n2)-c2cccc(Cl)c2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Warner SA, Eierman DF, Sovocool GW, Domnas AJ. Cycloartenol-derived sterol biosynthesis in the Peronosporales. Proc Natl Acad Sci U S A. 1982 Jun;79(12):3769-72.
molnova catalog



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