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V0162
CAS No. 147780-50-5
V0162( V 0162 | V-0162 | (R)-Mequitazine | VO-162 )
Catalog No. M12039 CAS No. 147780-50-5
A novel, high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameV0162
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NoteResearch use only, not for human use.
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Brief DescriptionA novel, high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21.
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DescriptionA novel, high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21; acts an inverse agonist for hM3R-mediated reporter gene activation (pIC50=7.56), with much the same efficacy as atropine, ipratropium and tiotropium, antagonizes acetylcholine-mediated contractions in a human bronchial preparation.COPD Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsV 0162 | V-0162 | (R)-Mequitazine | VO-162
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PathwayGPCR/G Protein
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TargetmAChR
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RecptormAChR
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number147780-50-5
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Formula Weight322.47
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Molecular FormulaC20H22N2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53
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Chemical Name10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Devillier P, et al. Respir Res. 2015 Jun 8;16:68.
2. Heusler P, et al. Pharmacol Res. 2015 Oct;100:117-26.
3. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.
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