Cart
sales@molnova.com
ML380
CAS No. 1627138-52-6
ML380( ML 380 | ML-380 )
Catalog No. M23721 CAS No. 1627138-52-6
ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 38 | In Stock |
|
| 5MG | 61 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 335 | In Stock |
|
| 100MG | 500 | In Stock |
|
| 500MG | 1098 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameML380
-
NoteResearch use only, not for human use.
-
Brief DescriptionML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).
-
DescriptionML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).
-
In VitroML380 (0.01 nM-100 μM) robustly stimulates inositol phosphate (IP) accumulation and Ca2+ mobilization in CHO-hM5 cells, with pEC50s of 5.33 and 5.71, respectively.ML380 (0.01-30 μM) increases the ACh-stimulated IP accumulation and Ca2+ mobilization in CHO-hM5 cells.
-
In VivoML380 (1 mg/kg; i.v.) displays high clearance (66 mL/min/kg), a moderate volume of distribution (1.6 L/kg), and a short half-life (t1/2, 22 min) in rats.
-
SynonymsML 380 | ML-380
-
PathwayGPCR/G Protein
-
TargetmAChR
-
RecptorM5 mAChR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1627138-52-6
-
Formula Weight494.53
-
Molecular FormulaC23H25F3N4O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO: 90 mg/mL?(181.99 mM;?Need ultrasonic)
-
SMILESCCN(C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2c(c1)cn[nH]2)Cc1ccccc1C(F)(F)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Berizzi AE, Gentry PR, Rueda P, Den Hoedt S, Sexton PM, Langmead CJ, Christopoulos A. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators. Mol Pharmacol. 2016 Oct;90(4):427-36. doi: 10.1124/mol.116.104182.
molnova catalog
related products
-
Fesoterodine maleate
Fesoterodine (PF-00695838) is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties.
-
Umeclidinium bromide
Umeclidinium bromide (GSK 573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs.
-
AZD 9164
A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0).
