
Urapidil
CAS No. 34661-75-1
Urapidil( —— )
Catalog No. M14189 CAS No. 34661-75-1
Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist.
Purity : >98% (HPLC)






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Biological Information
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Product NameUrapidil
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NoteResearch use only, not for human use.
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Brief DescriptionUrapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist.
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DescriptionUrapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist.(In Vitro):Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. Urapidil does not affect vascular tone at concentrations up to 10-5 M. Urapidil (10-5 M) markedly inhibits the alpha 1-adrenergic agonist (phenylephrine)-induced concentration-dependent contractions in aortic rings without endothelium and also to some extent in those with endothelium. Moreover, the inhibitory effect of Urapidil is more pronounced in rings without endothelium than in those with endothelium. Urapidil (10-5 M) affects neither the vascular tone nor the concentration-dependent contraction to serotonin.
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In VitroUrapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. Urapidil does not affect vascular tone at concentrations up to 10-5 M. Urapidil (10-5 M) markedly inhibits the alpha 1-adrenergic agonist (phenylephrine)-induced concentration-dependent contractions in aortic rings without endothelium and also to some extent in those with endothelium. Moreover, the inhibitory effect of Urapidil is more pronounced in rings without endothelium than in those with endothelium. Urapidil (10-5 M) affects neither the vascular tone nor the concentration-dependent contraction to serotonin.
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT| α-adrenergic receptor
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number34661-75-1
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Formula Weight387.48
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Molecular FormulaC20H29N5O3
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESCN1C(=CC(=O)N(C1=O)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. AG. Br J Pharmacol. 1991 Apr;102(4):998-1002.
molnova catalog



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