BRL54443

Research use only, not for human use.

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively; shows low affinity for other receptors 5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM); selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production with IC50 of 14 nM in DG membranes; significantly reduces formalin-induced flinching in rats.

BRL 54443;BRL-54443

Endocrinology/Hormones

5-HT Receptor

5-HT1A;5-HT1B;5-HT1D;5-HT1E;5-HT1F

Cardiovascular Disease

——

57477-39-1

230.31

C14H18N2O

>98% (HPLC)

DMSO: ≥ 51 mg/mL

CN1CCC(C2=CNC3=C2C=C(O)C=C3)CC1

1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-

(-20℃)

With Ice Pack

≥ 2 years