Uprosertib

CAS No. 1047634-65-0

Uprosertib ( GSK2141795, GSK 795, Uprosertib )

Catalog No. M17123 CAS No. 1047634-65-0

Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.

Purity : 97%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 69 In Stock
10MG 113 In Stock
25MG 191 In Stock
50MG 306 In Stock
100MG 507 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Uprosertib
  • Note
    Research use only, not for human use.
  • Brief Description
    Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
  • Description
    Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
  • Synonyms
    GSK2141795, GSK 795, Uprosertib
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Akt1; Akt2; Akt3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1047634-65-0
  • Formula Weight
    429.25
  • Molecular Formula
    C18H16Cl2F2N4O2
  • Purity
    97%
  • Solubility
    DMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL
  • SMILES
    Cn1c(c(cn1)Cl)c1c(oc(c1)C(=O)N[C@@H](Cc1cc(c(cc1)F)F)CN)Cl
  • Chemical Name
    N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.
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