Uprosertib( GSK2141795, GSK 795, Uprosertib )

Catalog No. M17123 CAS No. 1047634-65-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Uprosertib
Note

Research use only, not for human use.
Brief Description

Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
Description

Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
In Vitro

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In Vivo

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Synonyms

GSK2141795, GSK 795, Uprosertib
Pathway

Others
Target

Other Targets
Recptor

Akt1| Akt2| Akt3
Research Area

Cancer
Indication

——

CAS Number

1047634-65-0
Formula Weight

429.25
Molecular Formula

C18H16Cl2F2N4O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL
SMILES

Cn1c(c(cn1)Cl)c1c(oc(c1)C(=O)N[C@@H](Cc1cc(c(cc1)F)F)CN)Cl
Chemical Name

N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide

1.Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.

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