Uprosertib
CAS No. 1047634-65-0
Uprosertib ( GSK2141795, GSK 795, Uprosertib )
Catalog No. M17123 CAS No. 1047634-65-0
Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
Purity : 97%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 49 | In Stock |
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5MG | 69 | In Stock |
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10MG | 113 | In Stock |
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25MG | 191 | In Stock |
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50MG | 306 | In Stock |
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100MG | 507 | In Stock |
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200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameUprosertib
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NoteResearch use only, not for human use.
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Brief DescriptionUprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
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DescriptionUprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
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SynonymsGSK2141795, GSK 795, Uprosertib
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PathwayOthers
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TargetOther Targets
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RecptorAkt1; Akt2; Akt3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1047634-65-0
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Formula Weight429.25
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Molecular FormulaC18H16Cl2F2N4O2
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Purity97%
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SolubilityDMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL
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SMILESCn1c(c(cn1)Cl)c1c(oc(c1)C(=O)N[C@@H](Cc1cc(c(cc1)F)F)CN)Cl
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Chemical NameN-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.
molnova catalog
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