USP8-IN-22c

CAS No. 924296-17-3

USP8-IN-22c ( —— )

Catalog No. M16621 CAS No. 924296-17-3

A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 178 Get Quote
5MG 309 Get Quote
10MG 441 Get Quote
25MG 705 Get Quote
50MG 981 Get Quote
100MG 1332 Get Quote
500MG 2655 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    USP8-IN-22c
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM.
  • Description
    A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM; shows no inhibitory activity for USP7, USP5, SENP1, Uch-L3, and caspase 3 (IC50>100 uM), and displays partial activity against Uch-L3; inhibits the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50 values in the 0.5-1.5 uM range.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    924296-17-3
  • Formula Weight
    287.28
  • Molecular Formula
    C16H9N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 20.1 mg/mL
  • SMILES
    C=CCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N
  • Chemical Name
    9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(2-propen-1-yloxy)imino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.
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