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USP28-IN-4
CAS No. 2931509-15-6
USP28-IN-4( —— )
Catalog No. M36612 CAS No. 2931509-15-6
USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 85 | Get Quote |
|
| 5MG | 128 | Get Quote |
|
| 10MG | 202 | Get Quote |
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| 25MG | 394 | Get Quote |
|
| 50MG | 625 | Get Quote |
|
| 100MG | 963 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameUSP28-IN-4
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NoteResearch use only, not for human use.
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Brief DescriptionUSP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5.
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DescriptionUSP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331).
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In VitroWestern Blot Analysis Cell Line:Human colorectal cancer cells HCT116 and Ls174T Concentration:20 μM, 30 μM, 50 μM, and 60 μM, for Ls174T; 30 μM, 50 μM, 60 μM and 80 μM for HCT116 Incubation Time:24 h Result:Dose-dependently down-regulated the cellular level of c-Myc.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number2931509-15-6
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Formula Weight461.36
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Molecular FormulaC22H18Cl2N2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhou D, et al. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur J Med Chem. 2023 Jun 5;254:115369.?
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