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USP7-IN-8

CAS No. 2009273-60-1

USP7-IN-8( GNE-6776 )

Catalog No. M23902 CAS No. 2009273-60-1

USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	102	In Stock
5MG	93	In Stock
10MG	150	In Stock
25MG	283	In Stock
50MG	403	In Stock
100MG	551	In Stock
200MG	728	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

USP7-IN-8
Note

Research use only, not for human use.
Brief Description

USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
Description

USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
In Vitro

USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4.
In Vivo

——
Synonyms

GNE-6776
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

USP7
Research Area

——
Indication

——

Chemical Information

CAS Number

2009273-60-1
Formula Weight

348.4
Molecular Formula

C20H20N4O2
Purity

>98% (HPLC)
Solubility

DMSO:80mg/ml(230.08mM; need ultrasonic)
SMILES

CCc(c(-c(cc1)ccc1O)c(N)nc1)c1-c(cc1)cnc1C(NC)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Blake R , Lello P D , Drummond J , et al. USP7 INHIBITOR COMPOUNDS AND METHODS OF USE:, US20160272588[P]. 2016.

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