UR13870( —— )

Catalog No. M34461 CAS No. 755753-89-0

UR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice.

Purity : >98% (HPLC)

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Biological Information

Product Name

UR13870
Note

Research use only, not for human use.
Brief Description

UR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice.
Description

Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

p38 MAPK
Research Area

——
Indication

——

Chemical Information

CAS Number

755753-89-0
Formula Weight

398.41
Molecular Formula

C24H16F2N4
Purity

>98% (HPLC)
Solubility

——
SMILES

FC=1C=CC(=CC1)C2=NC3=NN(C=C3C(C=4C=CC(F)=CC4)=C2C=5C=CN=CC5)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. K Mihara, et al. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154(1):153-64.??

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