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p38 MAPK Inhibitor
CAS No. 219138-24-6
p38 MAPK Inhibitor( —— )
Catalog No. M34809 CAS No. 219138-24-6
p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 294 | In Stock |
|
| 10MG | 459 | In Stock |
|
| 25MG | 677 | In Stock |
|
| 50MG | 910 | In Stock |
|
| 100MG | 1209 | In Stock |
|
| 200MG | 1646 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Namep38 MAPK Inhibitor
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NoteResearch use only, not for human use.
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Brief Descriptionp38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.
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Descriptionp38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number219138-24-6
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Formula Weight365.79
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Molecular FormulaC20H13ClFN3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (54.68 mM; ultrasonic and adjust pH to 2 with 1M HCl)
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SMILESO=C1C(=C(NN1C2=CC=C(Cl)C=C2)C=3C=CN=CC3)C4=CC=C(F)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Emprumapimod
Emprumapimod (PF-07265803) is an orally active and specific inhibitor of mitogen-activated protein kinase p38α MAPK, inhibits LPS-induced production of IL-6, and can be used to study dilated cardiomyopathy induced by the LMNA gene.
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Eudesmin
Eudesmin shows antiinflammatory neuritogenic anticonvulsant and sedative effects the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK PKC and PKA pathways.
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VX-702
A potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α.
