p38 MAPK Inhibitor( —— )

Catalog No. M34809 CAS No. 219138-24-6

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Product Name

p38 MAPK Inhibitor
Note

Research use only, not for human use.
Brief Description

p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.
Description

p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

p38 MAPK
Research Area

——
Indication

——

CAS Number

219138-24-6
Formula Weight

365.79
Molecular Formula

C20H13ClFN3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 20 mg/mL (54.68 mM; ultrasonic and adjust pH to 2 with 1M HCl)
SMILES

O=C1C(=C(NN1C2=CC=C(Cl)C=C2)C=3C=CN=CC3)C4=CC=C(F)C=C4
Chemical Name

——

1. S E de Laszlo, et al. Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94.?

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