UNC6852

CAS No. 2688842-08-0

UNC6852 ( —— )

Catalog No. M26584 CAS No. 2688842-08-0

UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 260 In Stock
10MG 430 In Stock
25MG 710 In Stock
50MG 972 In Stock
100MG 1332 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    UNC6852
  • Note
    Research use only, not for human use.
  • Brief Description
    UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
  • Description
    UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.(In Vitro):UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2688842-08-0
  • Formula Weight
    394.4
  • Molecular Formula
    C22H22N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCc(n(Cc1ccccc1)c1ccc2)c(C(C(N)=O)=O)c1c2OCC(OC)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Osaki S, et al. L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats. J Nutr. 2001 Mar;131(3):796-9.
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