TFMB-(S)-2-HG( —— )

Catalog No. M34038 CAS No. 1445703-64-9

TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	45	In Stock
2MG	29	In Stock
5MG	46	In Stock
10MG	72	In Stock
25MG	149	In Stock
50MG	235	In Stock
100MG	350	In Stock
200MG	Get Quote	In Stock
500MG	737	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TFMB-(S)-2-HG
Note

Research use only, not for human use.
Brief Description

TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases.
Description

TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA Methyltransferase
Research Area

——
Indication

——

Chemical Information

CAS Number

1445703-64-9
Formula Weight

288.22
Molecular Formula

C13H11F3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (346.96 mM; Ultrasonic )
SMILES

FC(F)(F)c1cccc(COC(=O)[C@@H]2CCC(=O)O2)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.?

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