EPZ020411
CAS No. 1700663-41-7
EPZ020411 ( EPZ-020411 )
Catalog No. M12596 CAS No. 1700663-41-7
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 212 | In Stock |
|
10MG | 353 | In Stock |
|
100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameEPZ020411
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NoteResearch use only, not for human use.
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Brief DescriptionEPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM.
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DescriptionEPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7); dose-dependently decreases H3R2 methylation A375 cell line with IC50 of 0.637 uM, with no affect levels of PRMT6 expression; exhibits good bioavailability following subcutaneous dosing in rats making it a suitable tool for potential in vivo target validation studies.
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SynonymsEPZ-020411
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorPRMT6
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1700663-41-7
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Formula Weight442.59
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Molecular FormulaC25H38N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCNCCN(C)CC1=C(NN=C1)C2=CC=C(C=C2)OC3CC(C3)OCCC4CCOCC4
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Chemical Name1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Apr 6;6(6):655-9.
molnova catalog
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