UK-5099

CAS No. 56396-35-1

UK-5099 ( UK-5099, UK 5099, UK5099 )

Catalog No. M17544 CAS No. 56396-35-1

UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 37 In Stock
5MG 60 In Stock
10MG 87 In Stock
25MG 168 In Stock
50MG 305 In Stock
100MG 455 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    UK-5099
  • Note
    Research use only, not for human use.
  • Brief Description
    UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM).
  • Description
    UK-5099 is a specific and potent mitochondrial pyruvate carrier blocker (MCK blocker). The UK5099 treated cells showed significantly higher proportion of side population (SP) fraction and expressed higher levels of stemness markers Oct3/4 and Nanog. Chemosensitivity examinations revealed that the UK5099 treated cells became more resistant to chemotherapy compared to the non-treated cells. MPC blocker (UK5099) application may be an ideal model for Warburg effect studies
  • Synonyms
    UK-5099, UK 5099, UK5099
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MPC
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    56396-35-1
  • Formula Weight
    288.3
  • Molecular Formula
    C18H12N2O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 50 mg/mL. 173.43 mM; H2O : < 0.1 mg/mL
  • SMILES
    OC(=O)C(=Cc1cn(-c2ccccc2)c2ccccc12)C#N
  • Chemical Name
    2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Halestrap A P. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors[J]. Biochemical Journal, 1975, 148(1): 85-96.
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