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UK-5099

CAS No. 56396-35-1

UK-5099 ( UK-5099, UK 5099, UK5099 )

Catalog No. M17544 CAS No. 56396-35-1

UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 87 In Stock
25MG 168 In Stock
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Biological Information

  • Product Name
    UK-5099
  • Note
    Research use only, not for human use.
  • Brief Description
    UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM).
  • Description
    UK-5099 is a specific and potent mitochondrial pyruvate carrier blocker (MCK blocker). The UK5099 treated cells showed significantly higher proportion of side population (SP) fraction and expressed higher levels of stemness markers Oct3/4 and Nanog. Chemosensitivity examinations revealed that the UK5099 treated cells became more resistant to chemotherapy compared to the non-treated cells. MPC blocker (UK5099) application may be an ideal model for Warburg effect studies
  • Synonyms
    UK-5099, UK 5099, UK5099
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MPC
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    56396-35-1
  • Formula Weight
    288.3
  • Molecular Formula
    C18H12N2O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 50 mg/mL. 173.43 mM; H2O : < 0.1 mg/mL
  • SMILES
    OC(=O)C(=Cc1cn(-c2ccccc2)c2ccccc12)C#N
  • Chemical Name
    2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Halestrap A P. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors[J]. Biochemical Journal, 1975, 148(1): 85-96.
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