UK-5099
CAS No. 56396-35-1
UK-5099 ( UK-5099, UK 5099, UK5099 )
Catalog No. M17544 CAS No. 56396-35-1
UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 37 | In Stock |
|
5MG | 60 | In Stock |
|
10MG | 87 | In Stock |
|
25MG | 168 | In Stock |
|
50MG | 305 | In Stock |
|
100MG | 455 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameUK-5099
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NoteResearch use only, not for human use.
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Brief DescriptionUK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM).
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DescriptionUK-5099 is a specific and potent mitochondrial pyruvate carrier blocker (MCK blocker). The UK5099 treated cells showed significantly higher proportion of side population (SP) fraction and expressed higher levels of stemness markers Oct3/4 and Nanog. Chemosensitivity examinations revealed that the UK5099 treated cells became more resistant to chemotherapy compared to the non-treated cells. MPC blocker (UK5099) application may be an ideal model for Warburg effect studies
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SynonymsUK-5099, UK 5099, UK5099
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PathwayOthers
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TargetOther Targets
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RecptorMPC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number56396-35-1
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Formula Weight288.3
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Molecular FormulaC18H12N2O2
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Purity98%
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SolubilityDMSO : ≥ 50 mg/mL. 173.43 mM; H2O : < 0.1 mg/mL
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SMILESOC(=O)C(=Cc1cn(-c2ccccc2)c2ccccc12)C#N
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Chemical Name2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Halestrap A P. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors[J]. Biochemical Journal, 1975, 148(1): 85-96.
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