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(E)-Elafibranor
CAS No. 575474-82-7
(E)-Elafibranor ( R112; R112; R 112 )
Catalog No. M17545 CAS No. 575474-82-7
R112 is an ATP-competitive inhibitor of Syk kinase.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 113 | In Stock |
|
| 25MG | 207 | In Stock |
|
| 50MG | 311 | In Stock |
|
| 100MG | 462 | In Stock |
|
| 500MG | 972 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name(E)-Elafibranor
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NoteResearch use only, not for human use.
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Brief DescriptionR112 is an ATP-competitive inhibitor of Syk kinase.
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DescriptionR112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(i)] = 96 nmol/L).
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SynonymsR112; R112; R 112
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PathwayOthers
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TargetOther Targets
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RecptorSyk
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number575474-82-7
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Formula Weight312.3
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Molecular FormulaC16H13FN4O2
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Purity98%
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SolubilityDMSO : ≥ 41 mg/mL; 131.28 mM
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SMILESc1cc(cc(c1)O)Nc1nc(ncc1F)Nc1cc(ccc1)O
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Chemical Name3,3'-((5-fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rossi AB, et al. J Allergy Clin Immunol. 2006 Sep;118(3):749-55.
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