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UK-369003

CAS No. 334827-98-4

UK-369003 ( Gisadenafil besylate )

Catalog No. M14135 CAS No. 334827-98-4

UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UK-369003
  • Note
    Research use only, not for human use.
  • Brief Description
    UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM.
  • Description
    UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6; demonstrates efficacy in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).COPD Phase 2 Discontinued
  • Synonyms
    Gisadenafil besylate
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    334827-98-4
  • Formula Weight
    677.79
  • Molecular Formula
    C23H33N7O5S.C6H6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCC1=C2C(=NN1CCOC)C(=O)NC(=N2)C3=C(N=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC.C1=CC=C(C=C1)S(=O)(=O)O
  • Chemical Name
    5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rawson DJ, et al. Bioorg Med Chem. 2012 Jan 1;20(1):498-509.
2. Martínez-Salamanca JI, et al. Eur Urol. 2011 Sep;60(3):527-35.
3. Watson KJ, et al. Drug Metab Dispos. 2011 Jul;39(7):1203-13.
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