Cart
sales@molnova.com
UK-369003
CAS No. 334827-98-4
UK-369003 ( Gisadenafil besylate )
Catalog No. M14135 CAS No. 334827-98-4
UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 224 | Get Quote |
|
| 50MG | 799 | Get Quote |
|
| 100MG | 1206 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameUK-369003
-
NoteResearch use only, not for human use.
-
Brief DescriptionUK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM.
-
DescriptionUK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6; demonstrates efficacy in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).COPD Phase 2 Discontinued
-
SynonymsGisadenafil besylate
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research AreaInflammation/Immunology
-
IndicationCOPD
Chemical Information
-
CAS Number334827-98-4
-
Formula Weight677.79
-
Molecular FormulaC23H33N7O5S.C6H6O3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCCC1=C2C(=NN1CCOC)C(=O)NC(=N2)C3=C(N=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC.C1=CC=C(C=C1)S(=O)(=O)O
-
Chemical Name5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rawson DJ, et al. Bioorg Med Chem. 2012 Jan 1;20(1):498-509.
2. Martínez-Salamanca JI, et al. Eur Urol. 2011 Sep;60(3):527-35.
3. Watson KJ, et al. Drug Metab Dispos. 2011 Jul;39(7):1203-13.
2. Martínez-Salamanca JI, et al. Eur Urol. 2011 Sep;60(3):527-35.
3. Watson KJ, et al. Drug Metab Dispos. 2011 Jul;39(7):1203-13.
molnova catalog
related products
-
YM976
YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM).
-
Difamilast
Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).
-
Olprinone
Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB).
