Cart
sales@molnova.com
RPL-554
CAS No. 298680-25-8
RPL-554 ( LS-193855;RPL 554;RPL554 )
Catalog No. M13914 CAS No. 298680-25-8
RPL-554 (LS-193855, RPL554)is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRPL-554
-
NoteResearch use only, not for human use.
-
Brief DescriptionRPL-554 (LS-193855, RPL554)is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
-
DescriptionRPL-554 (LS-193855, RPL554)is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively; inhibits LPS-induced TNFα release from human monocytes with IC50 of 0.52 uM, and proliferation of human mononuclear cells to phytohemagglutinin (IC50=0.46 uM); significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs (10mg/kg).Asthma Phase 2 Clinical
-
SynonymsLS-193855;RPL 554;RPL554
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research AreaInflammation/Immunology
-
IndicationAsthma
Chemical Information
-
CAS Number298680-25-8
-
Formula Weight477.55
-
Molecular FormulaC26H31N5O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(N)NCCN1C(N(CCC2=C3C=C(OC)C(OC)=C2)C3=C/C1=N\C4=C(C)C=C(C)C=C4C)=O
-
Chemical Name9,10-Dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Boswell-Smith V, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):840-8.
2. Calzetta L, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):414-23.
3. Turner MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70.
2. Calzetta L, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):414-23.
3. Turner MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70.
molnova catalog
related products
-
UK-369003
UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM.
-
Tofimilast
Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively.
-
D 159687
D159687 is a selective?PDE4D?inhibitorhad a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.
