Cart
sales@molnova.com
Home - Products - Angiogenesis - PDE - RPL-554

RPL-554

CAS No. 298680-25-8

RPL-554 ( LS-193855;RPL 554;RPL554 )

Catalog No. M13914 CAS No. 298680-25-8

RPL-554 (LS-193855, RPL554)is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 963 Get Quote
50MG 1962 Get Quote
100MG 2520 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    RPL-554
  • Note
    Research use only, not for human use.
  • Brief Description
    RPL-554 (LS-193855, RPL554)is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
  • Description
    RPL-554 (LS-193855, RPL554)is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively; inhibits LPS-induced TNFα release from human monocytes with IC50 of 0.52 uM, and proliferation of human mononuclear cells to phytohemagglutinin (IC50=0.46 uM); significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs (10mg/kg).Asthma Phase 2 Clinical
  • Synonyms
    LS-193855;RPL 554;RPL554
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    298680-25-8
  • Formula Weight
    477.55
  • Molecular Formula
    C26H31N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N)NCCN1C(N(CCC2=C3C=C(OC)C(OC)=C2)C3=C/C1=N\C4=C(C)C=C(C)C=C4C)=O
  • Chemical Name
    9,10-Dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Boswell-Smith V, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):840-8.
2. Calzetta L, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):414-23.
3. Turner MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Bullatine A

    Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects.

  • PF 05180999

    PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.

  • SEP-0372814

    PDE10-IN-1 is PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1 for treating CNS and metabolic disorders.

Sign In Join Free