
UC-514321
CAS No. 299420-83-0
UC-514321( UC514321 )
Catalog No. M13922 CAS No. 299420-83-0
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 178 | In Stock |
![]() ![]() |
10MG | 338 | In Stock |
![]() ![]() |
25MG | 573 | In Stock |
![]() ![]() |
50MG | 799 | In Stock |
![]() ![]() |
100MG | 1107 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameUC-514321
-
NoteResearch use only, not for human use.
-
Brief DescriptionUC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5.
-
DescriptionUC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
-
In VitroCell Viability Assay Cell Line:MONOMAC-6, THP-1, KOCL-48, KASUMI-1, ML-2, and NB4 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Most significantly repressed MONOMAC-6 cell viability. Showed no inhibitory effect on the viability of TET1-low AML.RT-PCR Cell Line:MONOMAC-6 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Functioned as TET1-transcription inhibitors in TET1-high AMLs and their anti-leukemic effects are TET1-dependent.
-
In VivoAnimal Model:MLL-AF9-AML mice and AE9a-AML model.Dosage:2.5 mg/kg.Administration:IP., once per day, for 10 days. Result:Showed an improved therapeutic effect in AML mouse models in vivo. Prolonged the median survival over three fold.
-
SynonymsUC514321
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorSTAT
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number299420-83-0
-
Formula Weight441.568
-
Molecular FormulaC26H35NO5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?Ethanol : 50 mg/mL (113.23 mM)
-
SMILES——
-
Chemical Name6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
molnova catalog



related products
-
N-Methylcytisine
N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM).
-
Stafib-1
A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
-
NT219
NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of certain molecular chaperones and inhibits STAT3 phosphorylation NT219 is useful for the study of cancer and neurodegenerative diseases.