UC-514321

CAS No. 299420-83-0

UC-514321( UC514321 )

Catalog No. M13922 CAS No. 299420-83-0

UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 178 In Stock
10MG 338 In Stock
25MG 573 In Stock
50MG 799 In Stock
100MG 1107 In Stock
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Biological Information

  • Product Name
    UC-514321
  • Note
    Research use only, not for human use.
  • Brief Description
    UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5.
  • Description
    UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
  • In Vitro
    Cell Viability Assay Cell Line:MONOMAC-6, THP-1, KOCL-48, KASUMI-1, ML-2, and NB4 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Most significantly repressed MONOMAC-6 cell viability. Showed no inhibitory effect on the viability of TET1-low AML.RT-PCR Cell Line:MONOMAC-6 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Functioned as TET1-transcription inhibitors in TET1-high AMLs and their anti-leukemic effects are TET1-dependent.
  • In Vivo
    Animal Model:MLL-AF9-AML mice and AE9a-AML model.Dosage:2.5 mg/kg.Administration:IP., once per day, for 10 days. Result:Showed an improved therapeutic effect in AML mouse models in vivo. Prolonged the median survival over three fold.
  • Synonyms
    UC514321
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    299420-83-0
  • Formula Weight
    441.568
  • Molecular Formula
    C26H35NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 50 mg/mL (113.23 mM)
  • SMILES
    ——
  • Chemical Name
    6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
molnova catalog
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