UC-514321 ( UC514321 )

Catalog No. M13922 CAS No. 299420-83-0

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Datasheet

HNMR

HPLC

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Product Name

UC-514321
Note

Research use only, not for human use.
Brief Description

UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5.
Description

UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
Synonyms

UC514321
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

CAS Number

299420-83-0
Formula Weight

441.57
Molecular Formula

C26H35NO5
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol

1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.

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