STAT5 inhibitor 17f

Research use only, not for human use.

A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.

A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation; inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5; inhibits KU812 and K562 cell growth with IC50 of 9 and 5 uM, respectively, demonstrates highly potent antileukemic effect with minimal effects on bone marrow stromal cells.

Cell Viability Assay Cell Line:KG1a and MV-4-11 cell lines Concentration:100 nM, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM Incubation Time:48 hours Result:Inhibited cell growth in KG1a and MV-4-11 cell lines Apoptosis Analysis Cell Line:K562, KU812, KG1a and MV-4-11 cells Concentration:10 μMIncubation Time:48 hours Result:Significantly increased the number of apoptotic cells.Western Blot AnalysisCell Line:KG1a, MV-4-11 and KU812 cells Concentration:10 μM Incubation Time:24 hours Result:Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2.

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STAT5-IN-17f

JAK/STAT Signaling

STAT

STAT

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2111834-61-6

397.522

C26H27N3O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (251.57 mM)

CC1(C)CCN(CCOC2=CC3=C(NC=C3)C=C2)C4=C1C=C(C5=CC=CN=C5)C=C4

1-(2-((1H-Indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline

(-20℃)

With Ice Pack

≥ 2 years