Triptorelin ( AY 25650 )

Catalog No. M21742 CAS No. 57773-63-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Triptorelin
Note

Research use only, not for human use.
Brief Description

Triptorelin is a GnRHR agonist shown to inhibit estradiol-induced cancer cell proliferation.
Description

Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively). It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM. It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day. Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.
Synonyms

AY 25650
Pathway

Others
Target

Other Targets
Recptor

——
Research Area

——
Indication

——

CAS Number

57773-63-4
Formula Weight

1311.45
Molecular Formula

C64H82N18O13
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
Chemical Name

Glp-His-Trp-Ser-Tyr-D-Trp-Leu- Arg-Pro-Gly-NH2