Triclocarban

CAS No. 101-20-2

Triclocarban( 3,4,4′-Trichlorocarbanilide )

Catalog No. M17750 CAS No. 101-20-2

Triclocarban, an antimicrobial agent, is used in personal cleaning products.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Triclocarban
  • Note
    Research use only, not for human use.
  • Brief Description
    Triclocarban, an antimicrobial agent, is used in personal cleaning products.
  • Description
    Triclocarban, an antimicrobial agent, is used in personal cleaning products.(In Vitro):Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes. Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.(In Vivo):Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring.
  • In Vitro
    Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes.Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.
  • In Vivo
    Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of off spring.
  • Synonyms
    3,4,4′-Trichlorocarbanilide
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    101-20-2
  • Formula Weight
    315.58
  • Molecular Formula
    C13H9Cl3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 150 mg/mL; 475.32 mM
  • SMILES
    Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kanbara Y, et al. Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress. J Toxicol Sci. 2013 Feb;38(1):49-55.
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