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Tolbutamide

CAS No. 64-77-7

Tolbutamide( D 860 | NSC 23813 | NSC 87833 | U-2043 )

Catalog No. M15457 CAS No. 64-77-7

Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 37 In Stock
1G 53 In Stock
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Biological Information

  • Product Name
    Tolbutamide
  • Note
    Research use only, not for human use.
  • Brief Description
    Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.
  • Description
    Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.
  • In Vitro
    Western Blot Analysis Cell Line:Glioma cell Concentration:400 μM Incubation Time:24h Result:Increasing the level of Cx43.
  • In Vivo
    Animal Model:Non-obese-diabetic mouse Dosage:125 mg/kg Administration:Supplemented in daily diet for 27 weeks Result:Showed 10 of 23 animals developed diabetes compared with 18 of 24 in the control groups.Animal Model:Pregnant mice Dosage:100 mg/kg, 400 mg/kg Administration:Intraperitoneal injection (i.p.) Result:Showed a significant reduction (50 %) in the frequency of living fetuses for the group of 400 mg/kg on day 13.
  • Synonyms
    D 860 | NSC 23813 | NSC 87833 | U-2043
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    64-77-7
  • Formula Weight
    270.35
  • Molecular Formula
    C12H18N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 54 mg/mL warmed (199.74 mM); DMSO: 54 mg/mL (199.74 mM)
  • SMILES
    O=C(NS(=O)(C1=CC=C(C)C=C1)=O)NCCCC
  • Chemical Name
    1-butyl-3-(4-methylphenyl)sulfonylurea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wray HL, et al, Biochem Biophys Res Commun. 1973, 53(1), 291-294.
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