Tirasemtiv ( CK2017357; CK-2017357; CK 2017357; Tirasemtiv )

Catalog No. M17112 CAS No. 1005491-05-3

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Product Name

Tirasemtiv
Note

Research use only, not for human use.
Brief Description

Tirasemtiv(CK 2017357) is a small-molecule fast-skeletal-troponin activator, with a potential treatment for muscle weakness and neuromuscular dysfunction.
Description

Tirasemtiv, also known as CK2017357, is a novel skeletal muscle activator. Tirasemtiv slows the rate of calcium release from troponin, thus sensitizing fast skeletal muscle fibers to calcium. Tirasemtiv demonstrated increases in skeletal muscle force in response to neuronal input and delays in the onset and reductions in the degree of muscle fatigue.
Synonyms

CK2017357; CK-2017357; CK 2017357; Tirasemtiv
Pathway

Others
Target

Other Targets
Recptor

Troponin
Research Area

Neurological Disease
Indication

——

CAS Number

1005491-05-3
Formula Weight

230.27
Molecular Formula

C12H14N4O
Purity

98%
Solubility

DMSO : ≥ 52 mg/mL 225.82 mM
SMILES

CCC(CC)n1c2nc(cnc2[nH]c1=O)C#C
Chemical Name

1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo(4,5-b)pyrazin-2-one

1. Russell AJ, et al. Nat Med. 2012 Feb 19;18(3):452-5.

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