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Tilmacoxib
CAS No. 180200-68-4
Tilmacoxib ( JTE-522;RWJ57504 )
Catalog No. M12748 CAS No. 180200-68-4
Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTilmacoxib
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NoteResearch use only, not for human use.
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Brief DescriptionTilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM.
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DescriptionTilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM); significantly inhibits fibrosis, also inhibits growth of pulmonary metastases of colorectal cancer in rats.Rheumatoid Arthritis Phase 2 Discontinued
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SynonymsJTE-522;RWJ57504
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research AreaInflammation/Immunology
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IndicationRheumatoid Arthritis
Chemical Information
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CAS Number180200-68-4
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Formula Weight338.40
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Molecular FormulaC16H19FN2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=S(C1=CC=C(C2=C(C3CCCCC3)N=C(C)O2)C=C1F)(N)=O
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Chemical Name4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wakitani K, et al. Jpn J Pharmacol. 1998 Nov;78(3):365-71.
2. Kobayashi H, et al. BMC Cancer. 2005 Mar 3;5:26.
3. Yamamoto H, et al. Gastroenterology. 2003 Aug;125(2):556-71.
2. Kobayashi H, et al. BMC Cancer. 2005 Mar 3;5:26.
3. Yamamoto H, et al. Gastroenterology. 2003 Aug;125(2):556-71.
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