Tilmacoxib

Research use only, not for human use.

Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM.

Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM); significantly inhibits fibrosis, also inhibits growth of pulmonary metastases of colorectal cancer in rats.Rheumatoid Arthritis Phase 2 Discontinued

JTE-522;RWJ57504

Chromatin/Epigenetic

COX

COX

Inflammation/Immunology

Rheumatoid Arthritis

180200-68-4

338.40

C16H19FN2O3S

>98% (HPLC)

——

O=S(C1=CC=C(C2=C(C3CCCCC3)N=C(C)O2)C=C1F)(N)=O

4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years