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Naproxen sodium
CAS No. 26159-34-2
Naproxen sodium( Naproxen sodium | RS 3650 | Sodium naproxen | Naproxen natrium )
Catalog No. M13797 CAS No. 26159-34-2
Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | 32 | In Stock |
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Biological Information
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Product NameNaproxen sodium
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NoteResearch use only, not for human use.
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Brief DescriptionNaproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
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DescriptionNaproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.(In Vitro):Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively.(In Vivo):Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM).
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In VitroNaproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively.
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In VivoNaproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM).
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SynonymsNaproxen sodium | RS 3650 | Sodium naproxen | Naproxen natrium
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX-1| COX-2
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number26159-34-2
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Formula Weight252.24
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Molecular FormulaC14H13NaO3
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Purity>98% (HPLC)
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SolubilityWater: 50 mg/mL (198.22 mM); DMSO: 3 mg/mL (11.89 mM)
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SMILESO=C([O-])[C@@H](C)C1=CC=C2C=C(OC)C=CC2=C1.[Na+]
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Chemical Name2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mitchell JA, et al. Proc Natl Acad Sci, 1993, 90(24), 11693-11697.
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