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Theliatinib

CAS No. 1353644-70-8

Theliatinib ( —— )

Catalog No. M20712 CAS No. 1353644-70-8

Theliatinib a potent and highly selective EGFR inhibitor with anti-tumor activity. Ki of 0.05 nM for wild type EGFR and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 164 In Stock
10MG 268 In Stock
25MG 442 In Stock
50MG 656 In Stock
100MG 888 In Stock
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Biological Information

  • Product Name
    Theliatinib
  • Note
    Research use only not for human use.
  • Brief Description
    Theliatinib a potent and highly selective EGFR inhibitor with anti-tumor activity. Ki of 0.05 nM for wild type EGFR and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant respectively.
  • Description
    Theliatinib a potent and highly selective EGFR inhibitor with anti-tumor activity. Ki of 0.05 nM for wild type EGFR and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant respectively.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1353644-70-8
  • Formula Weight
    442.5
  • Molecular Formula
    C25H26N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:47 mg/mL (106.21 mM)
  • SMILES
    [H][C@]12CCN(C)[C@@]1([H])CN(C2)C(=O)Nc1cc2c(Nc3cccc(c3)C#C)ncnc2cc1OC
  • Chemical Name
    (3aR6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[34-b]pyrrole-5(1H)-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ren Y Zheng J Fan S et al. Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification.[J]. Oncotarget 2017 8(31):50832-50844.
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