Tetracycline( —— )

Catalog No. M15262 CAS No. 60-54-8

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Product Name

Tetracycline
Note

Research use only, not for human use.
Brief Description

Tetracycline is a naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Description

Tetracycline is a naphthacene antibiotic that inhibits amino acyltrna. binding during protein synthesis.(In Vitro):Tetracycline shows susceptibilfty of V. vulnlflcus strain B3547 with MIC value of 0.5g/mL.Tetracycline inhibits the L-amyloid aggregates formation and disassembles the pre-formed fibrils.(In Vivo):Tetracycline (3 mg/kg; i.p. every 12 h until survive) survives mice from bacteremia.
In Vitro

——
In Vivo

Animal Model:Female ICR mice weight 30 to 40 g with V.vulnificus strain B3547 infection Dosage:3 mg/kg Administration:Intraperitoneal injection; 3 mg/kg every 12h until surviveResult:Inhibited the growth of human CNE-2 xenografts in nude mice.
Synonyms

——
Pathway

Microbiology/Virology
Target

Other Targets
Recptor

Major prion protein| 16S ribosome| 30S ribosome
Research Area

Infection
Indication

——

CAS Number

60-54-8
Formula Weight

444.43
Molecular Formula

C22H24N2O8
Purity

>98% (HPLC)
Solubility

Soluble in Water
SMILES

C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
Chemical Name

——

1.Buck MA, Cooperman BS. Biochemistry. 1990 Jun 5;29(22):5374-9.

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