Tenovin-1

Research use only, not for human use.

Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2.

Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2; causes significantly greater growth inhibition, cell death via apoptosis, as well as superior p53 promoter upregulation in wtp53 MyLa cells when combined with vorinostat; elicits caspase-mediated cell death in p53 wild-type cells, but caspase-independent cell death in p53 null cells.

Tenovin 1

Chromatin/Epigenetic

Sirtuin

Mdm2;p53

Cancer

——

380315-80-0

369.48

C20H23N3O2S

>98% (HPLC)

10 mM in DMSO

O=C(NC(NC1=CC=C(NC(C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2

Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-

(-20℃)

With Ice Pack

≥ 2 years