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Tecovirimat

CAS No. 869572-92-9

Tecovirimat( ST-246 | ST246 | Tpoxx )

Catalog No. M16317 CAS No. 869572-92-9

Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxvirusesu.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tecovirimat
  • Note
    Research use only, not for human use.
  • Brief Description
    Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxvirusesu.
  • Description
    Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxviruses; ST-246 is active against multiple orthopoxviruses, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruse; inhibits the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping.Other Indication Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ST-246 | ST246 | Tpoxx
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    869572-92-9
  • Formula Weight
    376.335
  • Molecular Formula
    C19H15F3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (265.72 mM)
  • SMILES
    O=C(NN(C(C1C2C(C3)C3C(C=C2)C41)=O)C4=O)C5=CC=C(C(F)(F)F)C=C5
  • Chemical Name
    4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop(f)isoindol-2(1H)-yl)-benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yang G, et al. J Virol. 2005 Oct;79(20):13139-49. 2. Quenelle DC, et al. Antimicrob Agents Chemother. 2007 Feb;51(2):689-95. 3. Bailey TR, et al. J Med Chem. 2007 Apr 5;50(7):1442-4. 4. Quenelle DC, et al. Antimicrob Agents Chemother. 2007 Nov;51(11):4118-24.
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