Tecadenoson

CAS No. 204512-90-3

Tecadenoson( CVT-510 )

Catalog No. M23916 CAS No. 204512-90-3

Tecadenoson is a selective agonist of A1 adenosine receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 128 In Stock
5MG 215 In Stock
10MG 340 In Stock
25MG 575 In Stock
50MG 822 In Stock
100MG 1107 In Stock
500MG 2241 In Stock
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Biological Information

  • Product Name
    Tecadenoson
  • Note
    Research use only, not for human use.
  • Brief Description
    Tecadenoson is a selective agonist of A1 adenosine receptor.
  • Description
    Tecadenoson is a selective agonist of A1 adenosine receptor.
  • In Vitro
    In the atrial-paced isolated heart, Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41?nM) than to increase coronary conductance (EC50=200?nM). At concentrations of Tecadenoson (40?nM) and diltiazem (1?μM) that causes equal prolongation of S-H interval (~10?ms), diltiazem, but not Tecadenoson, significantly reduces left ventricular developed pressure (LVP) and markedly increases coronary conductance. Tecadenoson shortens atrial (EC50=73?nM) but not the ventricular monophasic action potentials (MAP).
  • In Vivo
    In atrial-paced anaesthetized guinea-pigs, intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson given at 50 μg/kg causes a significant bradycardia (50% decrease in heart rate at 25 min.
  • Synonyms
    CVT-510
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    A1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    204512-90-3
  • Formula Weight
    337.33
  • Molecular Formula
    C14H19N5O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:155 mg/mL (459.49 mM)
  • SMILES
    OC[C@H]([C@H]([C@H]1O)O)O[C@H]1n1c2ncnc(N[C@H]3COCC3)c2nc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Snowdy S, et al. A comparison of an A1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AVnodal conduction in guinea-pig. Br J Pharmacol. 1999 Jan;126(1):137-46.
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