
Tecadenoson
CAS No. 204512-90-3
Tecadenoson( CVT-510 )
Catalog No. M23916 CAS No. 204512-90-3
Tecadenoson is a selective agonist of A1 adenosine receptor.
Purity : >98% (HPLC)






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2MG | 128 | In Stock |
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5MG | 215 | In Stock |
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10MG | 340 | In Stock |
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25MG | 575 | In Stock |
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50MG | 822 | In Stock |
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100MG | 1107 | In Stock |
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500MG | 2241 | In Stock |
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Biological Information
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Product NameTecadenoson
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NoteResearch use only, not for human use.
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Brief DescriptionTecadenoson is a selective agonist of A1 adenosine receptor.
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DescriptionTecadenoson is a selective agonist of A1 adenosine receptor.
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In VitroIn the atrial-paced isolated heart, Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41?nM) than to increase coronary conductance (EC50=200?nM). At concentrations of Tecadenoson (40?nM) and diltiazem (1?μM) that causes equal prolongation of S-H interval (~10?ms), diltiazem, but not Tecadenoson, significantly reduces left ventricular developed pressure (LVP) and markedly increases coronary conductance. Tecadenoson shortens atrial (EC50=73?nM) but not the ventricular monophasic action potentials (MAP).
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In VivoIn atrial-paced anaesthetized guinea-pigs, intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson given at 50 μg/kg causes a significant bradycardia (50% decrease in heart rate at 25 min.
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SynonymsCVT-510
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorA1
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Research Area——
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Indication——
Chemical Information
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CAS Number204512-90-3
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Formula Weight337.33
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Molecular FormulaC14H19N5O5
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Purity>98% (HPLC)
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SolubilityDMSO:155 mg/mL (459.49 mM)
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SMILESOC[C@H]([C@H]([C@H]1O)O)O[C@H]1n1c2ncnc(N[C@H]3COCC3)c2nc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Snowdy S, et al. A comparison of an A1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AVnodal conduction in guinea-pig. Br J Pharmacol. 1999 Jan;126(1):137-46.
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