Derenofylline

Research use only, not for human use.

Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).

Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).

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Animal Model:5/6 nephrectomy rats Dosage:10 mg/kg/d Administration:Oral administration, mixed with food for 12 weeks Result:Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.

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Apoptosis

Adenosine Receptor

A1

Cardiovascular Disease

Congestive Heart Failure

251945-92-3

308.38

C18H20N4O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (324.28 mM)

O[C@H]1CC[C@@H](CC1)Nc1nc(nc2[nH]ccc12)-c1ccccc1

(1r4r)-4-((2-phenyl-1H-pyrrolo[23-d]pyrimidin-4-yl)amino)cyclohexan-1-ol

(-20℃)

With Ice Pack

≥ 2 years