Derenofylline( —— )

Catalog No. M21579 CAS No. 251945-92-3

Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Derenofylline
Note

Research use only, not for human use.
Brief Description

Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
Description

Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
In Vitro

——
In Vivo

Animal Model:5/6 nephrectomy rats Dosage:10 mg/kg/d Administration:Oral administration, mixed with food for 12 weeks Result:Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.
Synonyms

——
Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

A1
Research Area

Cardiovascular Disease
Indication

Congestive Heart Failure

Chemical Information

CAS Number

251945-92-3
Formula Weight

308.38
Molecular Formula

C18H20N4O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (324.28 mM)
SMILES

O[C@H]1CC[C@@H](CC1)Nc1nc(nc2[nH]ccc12)-c1ccccc1
Chemical Name

(1r4r)-4-((2-phenyl-1H-pyrrolo[23-d]pyrimidin-4-yl)amino)cyclohexan-1-ol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kalk P et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.

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