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Tasquinimod
CAS No. 254964-60-8
Tasquinimod( ABR-215050 | ABR215050 | ABR 215050 )
Catalog No. M13764 CAS No. 254964-60-8
An orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
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| 5MG | 86 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 207 | In Stock |
|
| 50MG | 306 | In Stock |
|
| 100MG | 468 | In Stock |
|
| 500MG | 1044 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTasquinimod
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NoteResearch use only, not for human use.
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Brief DescriptionAn orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM.
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DescriptionAn orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM; inhibits colocalization of N-CoR/HDAC3, thereby inhibiting deacetylation of histones and HDAC4 client transcription factors, such as HIF-1α.Prostate cancer Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsABR-215050 | ABR215050 | ABR 215050
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC4
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Research AreaCancer
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IndicationProstate Cancer
Chemical Information
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CAS Number254964-60-8
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Formula Weight406.3552
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Molecular FormulaC20H17F3N2O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 42 mg/mL
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SMILESO=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2OC)N(C)C3=CC=C(C(F)(F)F)C=C3
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Chemical Name3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Isaacs JT, et al. Prostate. 2006 Dec 1;66(16):1768-78.
2. Olsson A, et al. Mol Cancer. 2010 May 17;9:107.
3. Dalrymple SL, et al. Prostate. 2012 May 1;72(6):638-48.
4. Isaacs JT, et al. Cancer Res. 2013 Feb 15;73(4):1386-99.
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