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Tasquinimod

CAS No. 254964-60-8

Tasquinimod ( ABR-215050;ABR215050;ABR 215050 )

Catalog No. M13764 CAS No. 254964-60-8

An orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 58 In Stock
5MG 86 In Stock
10MG 123 In Stock
25MG 207 In Stock
50MG 306 In Stock
100MG 468 In Stock
500MG 1044 In Stock
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Biological Information

  • Product Name
    Tasquinimod
  • Note
    Research use only, not for human use.
  • Brief Description
    An orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM.
  • Description
    An orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM; inhibits colocalization of N-CoR/HDAC3, thereby inhibiting deacetylation of histones and HDAC4 client transcription factors, such as HIF-1α.Prostate cancer Phase 3 Clinical
  • Synonyms
    ABR-215050;ABR215050;ABR 215050
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC4
  • Research Area
    Cancer
  • Indication
    Prostate Cancer

Chemical Information

  • CAS Number
    254964-60-8
  • Formula Weight
    406.36
  • Molecular Formula
    C20H17F3N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 42 mg/mL
  • SMILES
    O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2OC)N(C)C3=CC=C(C(F)(F)F)C=C3
  • Chemical Name
    3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Isaacs JT, et al. Prostate. 2006 Dec 1;66(16):1768-78.
2. Olsson A, et al. Mol Cancer. 2010 May 17;9:107.
3. Dalrymple SL, et al. Prostate. 2012 May 1;72(6):638-48.
4. Isaacs JT, et al. Cancer Res. 2013 Feb 15;73(4):1386-99.
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