Chidamide ( CS055; CS-055; CS 055; HBI8000; HBI 8000; HBI-8000; Chidamide; Tucidinostat )

Catalog No. M15838 CAS No. 743420-02-2

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Product Name

Chidamide
Note

Research use only, not for human use.
Brief Description

Chidamide(CS055; HBI-8000) is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM).
Description

Chidamide(CS055; HBI-8000) is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on HDAC4/5/7/9/6(IC50>30 uM).
Synonyms

CS055; CS-055; CS 055; HBI8000; HBI 8000; HBI-8000; Chidamide; Tucidinostat
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC1; HDAC2; HDAC3; HDAC8
Research Area

Cancer
Indication

——

CAS Number

743420-02-2
Formula Weight

390.41
Molecular Formula

C22H19FN4O2
Purity

>98%(HPLC)
Solubility

DMSO: 10 mM
SMILES

O=C(NC1=CC(F)=CC=C1N)C2=CC=C(CNC(/C=C/C3=CC=CN=C3)=O)C=C2
Chemical Name

(E)-N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide

1. L, et al. Biochem Biophys Res Commun. 2010 Feb 5;392(2):190-5.

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