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Tafasitamab

CAS No. 1422527-84-1

Tafasitamab( —— )

Catalog No. M36830 CAS No. 1422527-84-1

Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tafasitamab
  • Note
    Research use only, not for human use.
  • Brief Description
    Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.
  • Description
    Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:NHL cell lines and primary CLL and MCL cells by γδ T cells Concentration:Incubation Time:2 h Result:Induced killing of NHL cell lines and primary CLL and MCL cells by γδ T cells.Cell Proliferation Assay Cell Line:SU-DHL-6cells Concentration:Incubation Time:72 h Result:Showed potent antiproliferative effects on tumor cell.Apoptosis Analysis Cell Line:SU-DHL-6cells Concentration:0-4 ng/m L Incubation Time:48 h Result:Showed potent antiproliferative effects due to caspase-induced apoptosis
  • In Vivo
    Animal Model:Disseminated Raji model.Dosage:2.5 μg/kg Administration:Tafasitamab (SC, once on Day 1, 2.5 μg/kg) Result:Showed antitumor activity in disseminated Raji model.Animal Model:Disseminated Ramos model.Dosage:10 mg/kg Administration:Tafasitamab (IV, on Days 3, 6, 10, 13, 17, and 20 at a dose of10 mg/kg)Result:Showed antitumor activity in disseminated Ramos model.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Immunology/Inflammation related
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1422527-84-1
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jung Hyun Her, et al. Tafasitamab mediates killing of B-cell non-Hodgkin's lymphoma in combination with γδ T cell or allogeneic NK cell therapy. Cancer Immunol Immunother. 2022 Mar 29.?
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