Tafasitamab

CAS No. 1422527-84-1

Tafasitamab( —— )

Catalog No. M36830 CAS No. 1422527-84-1

Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 651 Get Quote
5MG 1302 Get Quote
10MG 1758 Get Quote
25MG 2512 Get Quote
50MG 3386 Get Quote
100MG 4410 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Tafasitamab
  • Note
    Research use only, not for human use.
  • Brief Description
    Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.
  • Description
    Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:NHL cell lines and primary CLL and MCL cells by γδ T cells Concentration:Incubation Time:2 h Result:Induced killing of NHL cell lines and primary CLL and MCL cells by γδ T cells.Cell Proliferation Assay Cell Line:SU-DHL-6cells Concentration:Incubation Time:72 h Result:Showed potent antiproliferative effects on tumor cell.Apoptosis Analysis Cell Line:SU-DHL-6cells Concentration:0-4 ng/m L Incubation Time:48 h Result:Showed potent antiproliferative effects due to caspase-induced apoptosis
  • In Vivo
    Animal Model:Disseminated Raji model.Dosage:2.5 μg/kg Administration:Tafasitamab (SC, once on Day 1, 2.5 μg/kg) Result:Showed antitumor activity in disseminated Raji model.Animal Model:Disseminated Ramos model.Dosage:10 mg/kg Administration:Tafasitamab (IV, on Days 3, 6, 10, 13, 17, and 20 at a dose of10 mg/kg)Result:Showed antitumor activity in disseminated Ramos model.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Immunology/Inflammation related
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1422527-84-1
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jung Hyun Her, et al. Tafasitamab mediates killing of B-cell non-Hodgkin's lymphoma in combination with γδ T cell or allogeneic NK cell therapy. Cancer Immunol Immunother. 2022 Mar 29.?
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