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Tafasitamab
CAS No. 1422527-84-1
Tafasitamab( —— )
Catalog No. M36830 CAS No. 1422527-84-1
Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 651 | Get Quote |
|
| 5MG | 1302 | Get Quote |
|
| 10MG | 1758 | Get Quote |
|
| 25MG | 2512 | Get Quote |
|
| 50MG | 3386 | Get Quote |
|
| 100MG | 4410 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTafasitamab
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NoteResearch use only, not for human use.
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Brief DescriptionTafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.
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DescriptionTafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19.
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In VitroCell Cytotoxicity Assay Cell Line:NHL cell lines and primary CLL and MCL cells by γδ T cells Concentration:Incubation Time:2 h Result:Induced killing of NHL cell lines and primary CLL and MCL cells by γδ T cells.Cell Proliferation Assay Cell Line:SU-DHL-6cells Concentration:Incubation Time:72 h Result:Showed potent antiproliferative effects on tumor cell.Apoptosis Analysis Cell Line:SU-DHL-6cells Concentration:0-4 ng/m L Incubation Time:48 h Result:Showed potent antiproliferative effects due to caspase-induced apoptosis
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In VivoAnimal Model:Disseminated Raji model.Dosage:2.5 μg/kg Administration:Tafasitamab (SC, once on Day 1, 2.5 μg/kg) Result:Showed antitumor activity in disseminated Raji model.Animal Model:Disseminated Ramos model.Dosage:10 mg/kg Administration:Tafasitamab (IV, on Days 3, 6, 10, 13, 17, and 20 at a dose of10 mg/kg)Result:Showed antitumor activity in disseminated Ramos model.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | Immunology/Inflammation related
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Research Area——
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Indication——
Chemical Information
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CAS Number1422527-84-1
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jung Hyun Her, et al. Tafasitamab mediates killing of B-cell non-Hodgkin's lymphoma in combination with γδ T cell or allogeneic NK cell therapy. Cancer Immunol Immunother. 2022 Mar 29.?
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