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TROX-1

CAS No. 1309601-26-0

TROX-1( TROX 1 | TROX1 )

Catalog No. M11237 CAS No. 1309601-26-0

A potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    TROX-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM.
  • Description
    A potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM); inhibits omiga-conotoxin GVIA-sensitive calcium currents with greater potency under depolarized conditions (IC50=0.4 uM) in rat DRG neurons, blocks all Ca(v)2 family channels. reduces nociception in preclinical pain models, while sparing normal cardiac and behavioral functions.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TROX 1 | TROX1
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1309601-26-0
  • Formula Weight
    434.859
  • Molecular Formula
    C22H16ClFN6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N(C2=NNC=N2)C3=C(C=C(C4=CC=C(F)C(Cl)=C4)C=C3)[C@@]1(C)CC5=CN=CN=C5
  • Chemical Name
    (3R)-5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1H-1,2,4-triazol-3-yl)-1,3-dihydro-2H-indol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Abbadie C, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55. 2. Swensen AM, et al. Mol Pharmacol. 2012 Mar;81(3):488-97. 3. Patel R, et al. Neuroscience. 2015 Jun 25;297:47-57. 4. Rahman W, et al. Neuroscience. 2015 Oct 1;305:76-85.
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