Cart
sales@molnova.com
TROX-1
CAS No. 1309601-26-0
TROX-1( TROX 1 | TROX1 )
Catalog No. M11237 CAS No. 1309601-26-0
A potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | Get Quote |
|
| 50MG | 2142 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTROX-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM.
-
DescriptionA potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM); inhibits omiga-conotoxin GVIA-sensitive calcium currents with greater potency under depolarized conditions (IC50=0.4 uM) in rat DRG neurons, blocks all Ca(v)2 family channels. reduces nociception in preclinical pain models, while sparing normal cardiac and behavioral functions.
-
In Vitro——
-
In Vivo——
-
SynonymsTROX 1 | TROX1
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCalcium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1309601-26-0
-
Formula Weight434.859
-
Molecular FormulaC22H16ClFN6O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1N(C2=NNC=N2)C3=C(C=C(C4=CC=C(F)C(Cl)=C4)C=C3)[C@@]1(C)CC5=CN=CN=C5
-
Chemical Name(3R)-5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1H-1,2,4-triazol-3-yl)-1,3-dihydro-2H-indol-2-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Abbadie C, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55.
2. Swensen AM, et al. Mol Pharmacol. 2012 Mar;81(3):488-97.
3. Patel R, et al. Neuroscience. 2015 Jun 25;297:47-57.
4. Rahman W, et al. Neuroscience. 2015 Oct 1;305:76-85.
molnova catalog
related products
-
Trimebutine maleate
Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.
-
ω-Conotoxin GVIA
Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.
-
Mibefradil dihydroch...
Mibefradil dihydrochloride is an blocker of calcium channel with moderate selectivity for T-type Ca2+ channels (T-type and L-type currents with IC50s of 2.7 μM and 18.6 μM, respectively). Mibefradil dihydrochloride inhibits reversibly the T- and L-type currents with IC50 values of 2.7 and 18.6 μM, respectively.
