Cart
sales@molnova.com
DS16570511
CAS No. ——
DS16570511( —— )
Catalog No. M22676 CAS No. ——
DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.DS16570511 dose - dependent inhibition of serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 M.DS16570511 inhibits the uptake of isolated Ca2+. mitochondria from human cells, rat heart and pig heart.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 783 | In Stock |
|
| 10MG | 1308 | In Stock |
|
| 25MG | 1933 | In Stock |
|
| 50MG | Get Quote | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDS16570511
-
NoteResearch use only, not for human use.
-
Brief DescriptionDS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.DS16570511 dose - dependent inhibition of serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 M.DS16570511 inhibits the uptake of isolated Ca2+. mitochondria from human cells, rat heart and pig heart.
-
DescriptionDS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.DS16570511 dose - dependent inhibition of serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 M.DS16570511 inhibits the uptake of isolated Ca2+. mitochondria from human cells, rat heart and pig heart.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
Recptormitochondrial calcium uniporter
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight562.44
-
Molecular FormulaC30H25Cl2N3O4
-
Purity>98% (HPLC)
-
SolubilityDMSO:124 mg/mL(220.47 mM)
-
SMILESCc1onc(c1CNc1cccc(c1)C(=O)c1cn(CCCC(O)=O)c2ccccc12)-c1c(Cl)cccc1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kon N, et al. DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter. Cell Death Discov. 2017 Jul 17;3:17045.
molnova catalog
related products
-
ω-Agatoxin IVA
Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.
-
JTV-519 fumarate
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).
-
Azumolene
Azumolene1.EU4093 (azumolene sodium) is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.?2.?The effect of EU4093 on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.?
