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TRAM-34

CAS No. 289905-88-0

TRAM-34( TRAM-34 | TRAM34 | TRAM 34 )

Catalog No. M18371 CAS No. 289905-88-0

TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TRAM-34
  • Note
    Research use only, not for human use.
  • Brief Description
    TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.
  • Description
    TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli, and does not block cytochrome P450.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TRAM-34 | TRAM34 | TRAM 34
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IKCa1 (KCa3.1)
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    289905-88-0
  • Formula Weight
    344.84
  • Molecular Formula
    C22H17ClN2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 3.5 mg/mL; 10.15 mM
  • SMILES
    n1(nccc1)C(c1ccccc1)(c1ccccc1)c1c(cccc1)Cl
  • Chemical Name
    1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wulff H, et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.
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