TRAM-34 ( TRAM-34; TRAM34; TRAM 34 )

Catalog No. M18371 CAS No. 289905-88-0

TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.

Purity : 98%

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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25MG	73	In Stock
50MG	133	In Stock
100MG	176	In Stock
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500MG	383	In Stock
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Biological Information

Product Name

TRAM-34
Note

Research use only, not for human use.
Brief Description

TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.
Description

TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli, and does not block cytochrome P450.
Synonyms

TRAM-34; TRAM34; TRAM 34
Pathway

Others
Target

Other Targets
Recptor

IKCa1 (KCa3.1)
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

289905-88-0
Formula Weight

344.84
Molecular Formula

C22H17ClN2
Purity

98%
Solubility

DMSO : ≥ 3.5 mg/mL; 10.15 mM
SMILES

n1(nccc1)C(c1ccccc1)(c1ccccc1)c1c(cccc1)Cl
Chemical Name

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wulff H, et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.

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