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RR-11a analog
CAS No. 685543-66-2
RR-11a analog( aza-peptide Michael acceptor, 7a )
Catalog No. M26423 CAS No. 685543-66-2
RR-11a analog is a potent and selective asparaginyl endopeptidases (AE) (Legumain) inhibitors(IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 410 | Get Quote |
|
| 10MG | 565 | Get Quote |
|
| 25MG | 1044 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2601 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRR-11a analog
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NoteResearch use only, not for human use.
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Brief DescriptionRR-11a analog is a potent and selective asparaginyl endopeptidases (AE) (Legumain) inhibitors(IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively).
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DescriptionRR-11a analog is a potent and selective asparaginyl endopeptidases (AE) (Legumain) inhibitors(IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively).(In Vivo):RR-11a analog shows a t1/2 of 3-10 min.
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In Vitro——
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In VivoRR-11a analog has a half-live of 3-10 min.
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Synonymsaza-peptide Michael acceptor, 7a
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PathwayOthers
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TargetOther Targets
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RecptorLigands for Target Protein for PROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number685543-66-2
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Formula Weight491.501
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Molecular FormulaC22H29N5O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (254.33 mM)
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SMILESCCOC(=O)\C=C\C(=O)N(CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80.
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