BI-9564 ( BI 9564;BI9564 )

Catalog No. M12927 CAS No. 1883429-22-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BI-9564
Note

Research use only, not for human use.
Brief Description

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.
Description

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM; displays 45-fold selectiveity over BRD7, and >5,000-fold over BRD4-BD1, BRD4-BD2, and BRD2-BD1; blocks EOL-1 cell proliferation with EC50 of 0.8 uM, and displays antitumor activity in an AML xenograft model.
Synonyms

BI 9564;BI9564
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRD7;BRD9;CECR2
Research Area

Cancer
Indication

——

CAS Number

1883429-22-8
Formula Weight

353.41
Molecular Formula

C20H23N3O3
Purity

>98% (HPLC)
Solubility

DMSO: 7.2 mg/mL (Need warming)
SMILES

O=C1N(C)C=C(C2=CC(OC)=C(CN(C)C)C=C2OC)C3=CC=NC=C13
Chemical Name

4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one

1. Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75.
2. Krmer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.

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