TP003

Research use only, not for human use.

TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2.

TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2, has no affinity for α4β3γ2 and α6β3γ2 (Ki>1 uM); produces a robust anxiolytic-like effect in both rodent and non-human primate behavioral models of anxiety, also retains efficacy in a stress-induced hyperthermia model.Epilepsy Discontinued.

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TP 003

Membrane Transporter/Ion Channel

GAT

GAT

Neurological Disease

Epilepsy

628690-75-5

407.396

C23H16F3N3O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (245.47 mM)

N#CC1=CC(F)=CC=C1C2=CC(C3=CN=C4C(F)=C(C(C)(O)C)C=CN43)=CC=C2F

2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile

(-20℃)

With Ice Pack

≥ 2 years