TP-472 ( TP472 )

Catalog No. M13237 CAS No. 2079895-62-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TP-472
Note

Research use only, not for human use.
Brief Description

TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM; BRD7 KD=340 nM by ITC).
Description

TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM; BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay); has a good PK profile and is suitable for in vivo applications.
Synonyms

TP472
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

2079895-62-6
Formula Weight

333.39
Molecular Formula

C20H19N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(C=C(C=C1)C(=O)NC2CC2)C3=C4N=CC=CN4C(=C3)C(=O)C
Chemical Name

3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

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