TJ191

CAS No. 1522415-97-9

TJ191( —— )

Catalog No. M23656 CAS No. 1522415-97-9

TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 In Stock
5MG 58 In Stock
10MG 87 In Stock
25MG 177 In Stock
50MG 295 In Stock
100MG 484 In Stock
500MG 1035 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TJ191
  • Note
    Research use only, not for human use.
  • Brief Description
    TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
  • Description
    TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
  • In Vitro
    TJ191(0-100 μM; 24 hours) exhibits pronounced anti-proliferative activity in malignant?cell?lines, the IC50 values are 0.13 μM, 0.13±0.08 μM, 0.26±0.19 μM, 0.22±0.11 μM, 1.5±0.02 μM, 0.32±0.086 μM, 3.1±0.5 μM, 0.26±0.16 μM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50=17±10 μM) and MT-4 (IC50=47 ± 5 μM) cells.TJ191 (0.1-3 μM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 μM, TJ191 induces the maximum apoptotic rate of 80% after 24 h. Cell Viability Assay Cell Line:Malignant T-cell leukemia/lymphoma cells Concentration:0.01 μM, 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:24 hours Result:Exhibited inhibitory effects in drug-sensitive cells with IC50 ranging 0.13 μM to 3.1 μM. Apoptosis Analysis Cell Line:CEM cell line Concentration:0.1-3 μM Incubation Time:8 or 24 hoursResult:Led to cell apoptosis.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1522415-97-9
  • Formula Weight
    255.38
  • Molecular Formula
    C13H21NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    CCCCCCCC1=CC(C(OC)=O)=C(N)S1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ahmed El-Gazzar, et al. 2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. Oncotarget. 2017 Dec 15;9(5):6259-6269.
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