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THPP-1
CAS No. 1257051-63-0
THPP-1 ( —— )
Catalog No. M22050 CAS No. 1257051-63-0
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
|
| 5MG | 65 | Get Quote |
|
| 10MG | 110 | Get Quote |
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| 25MG | 237 | Get Quote |
|
| 50MG | 402 | Get Quote |
|
| 100MG | 593 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTHPP-1
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NoteResearch use only, not for human use.
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Brief DescriptionTHPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
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DescriptionTHPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively). Consistent with rodent data, both THPP-1 and risperidone significantly attenuated the stimulant effects in SIMA when administered alone, though some differences were noted.?Combination therapy with a low dose of risperidone produced significantly more robust effects.?THPP-1 and risperidone also produced a marked reduction of wake cycle time and gamma frequency power in EEG.?However, THPP-1 differed from risperidone by reducing spectral power of lower frequencies.
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE10A
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Research Area——
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Indication——
Chemical Information
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CAS Number1257051-63-0
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Formula Weight464.9
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Molecular FormulaC23H21ClN6O3
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Purity>98% (HPLC)
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SolubilityDMSO:31 mg/mL (66.68 mM; Need ultrasonic)
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SMILESCOCCOC1=C2CN(CCC2=NC(=N1)C1=CC=C(Cl)N=C1)C(=O)C1=C2C=CC=CN2C=N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity. Psychopharmacology (Berl). 2016 Jul;233(13):2441-50.
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