TH5487

CAS No. 2304947-71-3

TH5487 ( —— )

Catalog No. M21183 CAS No. 2304947-71-3

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 51 Get Quote
5MG 86 Get Quote
10MG 147 Get Quote
25MG 287 Get Quote
50MG 520 Get Quote
100MG 750 Get Quote
500MG 1521 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    TH5487
  • Note
    Research use only not for human use.
  • Brief Description
    TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM).
  • Description
    TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    8-oxoguanine DNA glycosylase 1 (OGG1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2304947-71-3
  • Formula Weight
    541.18
  • Molecular Formula
    C19H18BrIN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:25 mg/mL (46.20 mM; Need ultrasonic)
  • SMILES
    O=C(Nc1ccc(I)cc1)N1CCC(n2c(=O)[nH]c3c(Br)cccc32)CC1
  • Chemical Name
    4-(4-Bromo-23-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Visnes T et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.
molnova catalog
related products
  • Pseudoginsenoside Rh...

    Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway.

  • 6-TAMRA

    6-TAMRA has been a widely used fluorophore for preparing bioconjugates, especially fluorescent antibody and avidin derivatives used in immunochemistry.

  • Dihydroxyfumaric aci...

    Dihydroxyfumaric acid is a known generator of superoxide anions and by hydroxyl free radicals. Dihydroxyfumarate exposure can cause insulin inhibitory effects. It can spontaneously convert to hydroxypyruvate or to oxaloglycolate.